浙江大學(xué)化學(xué)系研究生導(dǎo)師：祝瑩 正文

　　姓名：?，?/strong>
　　單位：化學(xué)系
　　職稱：特聘副研究員，碩士生導(dǎo)師

　　基本信息
　　個(gè)人簡(jiǎn)介
　　Research ID
　　http://www.researcherid.com/rid/B-6637-2011
　　2013.1-至今 浙江大學(xué)，化學(xué)系，特聘副研究員，碩士生導(dǎo)師
　　2010.6-2013.1 浙江大學(xué)，控制系，智能系統(tǒng)與控制研究所，博士后（導(dǎo)師，方群教授，牟穎教授）
　　2012.1-2012.4 National University of Singapore（新加坡國(guó)立大學(xué)），化學(xué)系，訪問(wèn)學(xué)者（合作導(dǎo)師，Prof. Shaoqin Yao）
　　2005.9-2010.6 浙江大學(xué)，化學(xué)系，微分析系統(tǒng)研究所，博士（導(dǎo)師，方群教授）
　　2001.9-2005.6 浙江大學(xué)，化學(xué)系，學(xué)士

　　工作研究領(lǐng)域
　?。?）超微量、高通量的微流控篩選儀器，并用于藥物篩選和蛋白質(zhì)結(jié)晶篩選；
　?。?）新型微型化電噴霧質(zhì)譜離子源的研制以及用于藥物篩選和單細(xì)胞分析；
　?。?）基于激光誘導(dǎo)熒光的單分子和單細(xì)胞分析方法；
　?。?）基于微流控芯片的微型化色譜分離和檢測(cè)裝置。

　　聯(lián)系方式
　　電話：+86+57188206771
　　電子信箱：yingzhu@zju.edu.cn

　　研究成果
　　1. 超微量、高通量微流控液體操縱和檢測(cè)裝置
　　研制了一種基于液滴微流控技術(shù)的全自動(dòng)液體操縱和檢測(cè)裝置。該裝置可高度可靠的進(jìn)行皮升級(jí)液體定量量取、混合、轉(zhuǎn)移、檢測(cè)、以及生化篩選。與常規(guī)基于384孔板的篩選系統(tǒng)相比，其試樣消耗降低了37000倍以上。目前，該裝置獲得了2011年度浙江大學(xué)自研自制儀器設(shè)備優(yōu)秀成果獎(jiǎng)。

　　實(shí)驗(yàn)室介紹
　　浙江大學(xué)紫金港校區(qū)化學(xué)樓101 房間（Lab）
　　浙江大學(xué)紫金港校區(qū)化學(xué)樓104房間（Office）

　　發(fā)表論文
　　2013
　　[1] Yingzhu, Yunxia Zhang, Longfei Cai, Qun Fang, Sequential Operation Droplet Array: An Automated Microfluidic Platform for Picoliter-Scale Liquid Handling, Analysis, and Screening, Analytical Chemistry, 2013, 85(14): 6723–6731 fck_filebrowser.php
　　[2] Ying Zhu,* Nian-Nian Chen,* Qi Li, Qun Fang, Improving the sensitivity of confocal laser induced fluorescence detection to sub-picomolar scale for round capillaries by laterally shifting laser focus point, Analyst, 2013, 138, 4642-4648fck_filebrowser.php (*coauthors)
　　[3] Ying Zhu, Qun Fang, Analytical detection techniques for droplet microfluidics—A review, Analytica Chimica Acta, 2013, 787, 24-35 fck_filebrowser.php
　　[4] Yuan Su, Ying Zhu, Qun Fang, A multifunctional microfluidic droplet-array chip for analysis by electrospray ionization mass spectrometry, Lab on a Chip, 2013, 13(10), 1876-1882
　　[5] Qi Li, Ting Zhang, Ying Zhu, Qun Fang, Automated high-speed CE system for multiple samples, Electrophoresis, 2013, 34(4), 557-561
　　2012
　　[1]Ying Zhu, Hong Chen, Guansheng Du, Qun Fang. Microfluidic Droplet-Array Liquid-Liquid Chromatography based on Droplet Trapping Technique. Lab on a Chip, 2012, 12(21): 4350–4354fck_filebrowser.php
　　[2]Long-fei Cai,* Ying Zhu,* Qun Fang, Droplet-Based Microfluidic Flow Injection System with Large-Scale Concentration Gradient by a Single Nanoliter-Scale Injection for Enzyme Inhibition Assay, Analytical Chemistry, 2012, 84(1): 446-452 (*同等貢獻(xiàn))fck_filebrowser.php
　　[3] Xiuli Wang, Ying Zhu, Qun Fang, Valveless gated injection for microfluidic chip-based liquid chromatography system with polymer monolithic column, Journal of Chromatography A, 2013, 1246, 123-128
　　[4]Ji-feng Fan, Ying Zhu, Xiao-tong Shi, Qun Fang, Jiang Huang, Microfluidic sequential injection analysis system based on polydimethylsiloxane (PDMS) chip with integrated pneumatic-actuated valves, Science china-chemistry, 2012, 55(4): 531-536
　　2011
　　[1]Yun-xia Zhang,* Ying Zhu,* Bo Yao, Qun Fang. Droplet Array for Real Time Reverse Transcription Polymerase Chain Reaction, Lab on a Chip, 2011, 11(8):1545-1559 (*同等貢獻(xiàn))
　　[2]Ze-Qi Yu, Ying Zhu, Yunxia Zhang, Juan Li, Qun Fanga, Jianzhong Xi, Bo Yao, Nanoliter droplet array for microRNA detection based on enzymatic stem-loop probes ligation and SYBR Green real-time PCR, Talanta, 2011, 85 (4): 1760-1765
　　[3]Shu-Qing Gu, Yun-Xia Zhang, Ying Zhu, Wen-Bin Du, Bo Yao, Qun Fang, Multifunctional picoliter droplet manipulation platform and its application in single cell analysis. Analytical Chemistry, 2011, 83(19):7570-7576
　　[4]Xin-Jue Wang, Ying Zhu, Qun Fang, Developments and applications of microfluidic chip-based chromatographic technique, Chinese Journal of Chromatography, 2011, 29(2): 99-104
　　2010
　　[1]Ying Zhu, Qun Fang. Integrated Droplet Analysis System with Electrospray Ionization-Mass Spectrometry Using a Hydrophilic Tongue-Based Droplet Extraction Interface. Analytical Chemistry, 2010, 82(19): 8361-8366fck_filebrowser.php
　　[2]Ying Zhu, Jian-zhang Pan, Yuan Su, Qiao-hong He, Qun Fang. Fabrication of Low-Melting-Point Alloy Microelectrode and Monolithic Spray Tip for Integration of Glass Chip with Electrospray Ionization Mass Spectrometry. Talanta, 2010, 81(3):1069-1075fck_filebrowser.php
　　[3]Wen-bin Du,* Meng Sun,* Shu-qing Gu,* Ying Zhu,* Fang Qun. Automated Microfluidic Screening Assay Platform Based on DropLab. Analytical Chemistry, 2010, 82(23): 9941-9947 (*同等貢獻(xiàn)）
　　[4]Qing-Hu Lin, Yong-Qiang Cheng, Ya-Ni Dong, Ying Zhu, Jian-Zhang Pan, Qun Fang, High-speed separation of proteins by sodium dodecyl sulfate-capillary gel electrophoresis with partial translational spontaneous sample injection, Electrophoresis, 2011, 32(20): 2898-2903

　　會(huì)議論文
　　[1]Qun Fang, Ying Zhu, Hong Chen. Microfluidic chip-based droplet-array liquid-liquid chromatography. Proceedings of the First Shenyang International Colloquium on Microfluidics. Shenyang, China, 2007, 256~258（報(bào)展）
　　[2]Ying Zhu, Jian-Zhang Pan, Yuan Su, Qun Fang. A microfluidic chip based electrospray interface for mass spectrometry with a low-temperature alloy microelectrode. Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences. San Diego, USA, 2008, 976~978（報(bào)展）
　　[3]Ying Zhu, Hong Chen, Qun Fang. Droplet-array liquid chromatography on a microfluidic chip using droplet trapping technique. The 33rd International Symposium on High Performance Liquid Phase Separations and Related Techniques. Kyoto, Japan, 2008, 147 （口頭報(bào)告）
　　[4]Ying Zhu, Jian-Zhang Pan, Yuan Su, Qun Fang. A novel interface for electrospray ionization mass spectrometry on a microfluidic glass chip. The 5th National Conference on Micro-Total Analytical Systems, Nanjing, China, 2008, 188（報(bào)展）
　　[5]Ying Zhu, Hong Chen, Qun Fang. Droplet-array liquid chromatography on a microchip. Thirteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences. Jeju, Korea, 2009, 1470~1472（報(bào)展）
　　[6]Ying Zhu, Qun Fang. Droplet analysis with electrospray ionization mass spectrometry using an integrated glass microchip, Fourteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences. Groningen, The Netherlands, 2010, 1352~1354 (口頭報(bào)告)
　　[7]Ying Zhu, Qun Fang, Integrated microfluidic chip for droplet analysis based on electrospray ionization mass spectrometry, The 6th National Conference on Micro-Total Analytical Systems, Shanghai, China, 2010（報(bào)展）
　　[8]Yuan Su, Ying Zhu, Qun Fang, A multifunctional microfluidic droplet array system with ESI-MS detection, Fifteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences. Seattle, USA, 2011, 586~589（報(bào)展）
　　[9]Yun-Xia Zhang, Ying Zhu, Bo Yao, Qun Fang. Nanoliter droplet array for digital PCR. The 37rd International Symposium on High Performance Liquid Phase Separations and Related Techniques. Dalian, 2011, 316（報(bào)展）
　　[10]Xiu-Li Wang, Ying Zhu, Qun Fang. Microchip-based valveless high performance liquid chromatography system with gated injection. The 37rd International Symposium on High Performance Liquid Phase Separations and Related Techniques. Dalian, 2011, 315（報(bào)展）
　　[11]Ying Zhu, Yunxia Zhang, Longfei Cai, Qun Fang, High throughput and picoliter-scale drug screening with automated droplet microarray system, The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Okinawa, Japan, 2012, 389-391（報(bào)展）
　　[12]Yun-Xia Zhang, Ying Zhu, Qun Fang, Bo Yao, Single cell microRNA quantification with two step RT-Q-PCR based on flexible nanoliter-scale droplet array system, The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Okinawa, Japan, 2012, 428-430（報(bào)展）
　　[13]Xiu-Li Wang, Ying Zhu, Qun Fang, Droplet analysis system using liquid chromatography and mass spectrometry for enzyme inhibition assay, The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Okinawa, Japan, 2012, 1921-1923（報(bào)展）
　　[14]Li-na Zhu, Ying Zhu, Qun Fang Nanoliter-Scale Screening of Protein Crystallization with Sequential Operation Droplet Array, The 5th International Symposium on Microchemistry and Microsystems, Xiamen, China, 2013 （報(bào)展, CHEMINAS POSTER AWARD）
　　[15]Ying Zhu, Nian-nian Chen, Qi Li, and Qun Fang, Laterally Shifting Laser Focus Point on Round Capillary can Improve the Sensitivity of Confocal Laser Induced Fluorescence Detection to Sub-picomolar Scale, The 5th International Symposium on Microchemistry and Microsystems, Xiamen, China, 2013 （口頭報(bào)告）

　　研究生招生
　　每年招收碩士生2~3名，博士生1~2名，歡迎對(duì)分析儀器研制、微流控分析新方法、質(zhì)譜分析學(xué)研究有興趣的同學(xué)報(bào)考
　　正在進(jìn)行的研究項(xiàng)目
　　1．多通道微量液滴點(diǎn)樣儀的研制
　　2．高通量電噴霧質(zhì)譜分析系統(tǒng)的研究
　　3．蛋白質(zhì)結(jié)晶新方法研究

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