姓名：石桂秀
性別：男
職稱：教授
學(xué)院：廈門市第一醫(yī)院
研究方向：風(fēng)濕病病機(jī)與治療研究


個(gè)人簡介：

石桂秀教授簡介 石桂秀， 博士，教授/博導(dǎo)。1992年于蘇州醫(yī)學(xué)院獲醫(yī)學(xué)碩士學(xué)位。畢業(yè)后任大連大學(xué)醫(yī)學(xué)院中山醫(yī)院醫(yī)師，主治醫(yī)師，自1995年起任該院臨床免疫科主任。2000底至2004年7月，于加拿大蒙特利爾大學(xué)醫(yī)學(xué)中心(CHUM of University of Montreal) 師從Jiangping Wu教授，攻讀免疫學(xué)博士學(xué)位，并于2004年獲得博士學(xué)位。2004年8月至2007年1月于美國Trudeau研究院師從Frances E. Lund教授作博士后。2007年2月至8月于美國德克薩斯大學(xué)(University of Texas) El Paso分校任助理教授。2007年9月回國任四川大學(xué)華西醫(yī)院風(fēng)濕免疫科教授，博士生導(dǎo)師, 并被遴選為四川省衛(wèi)生廳學(xué)術(shù)帶頭人，現(xiàn)任四川省免疫學(xué)會(huì)理事長，中國免疫學(xué)會(huì)常務(wù)理事，成都市醫(yī)學(xué)會(huì)風(fēng)濕病專委會(huì)主任委員，國家自然基金會(huì)審（終審）評委。2011年獲“廈門雙百”創(chuàng)新人才稱號。并被聘為廈門大學(xué)醫(yī)學(xué)院教授，廈門大學(xué)第一醫(yī)院主任醫(yī)師。同年被聘為福建中醫(yī)藥大學(xué)碩士/博士生導(dǎo)師。目前的研究方向： 1.免疫調(diào)控與免疫應(yīng)答；2.自身免疫病的發(fā)病機(jī)制及治療學(xué)研究。

在研科研項(xiàng)目：

1）、30830094/C080701 《Gaq對B細(xì)胞分化的調(diào)控及其與自身免疫病的關(guān)系》 國家自然科學(xué)基金重點(diǎn)項(xiàng)目。課題負(fù)責(zé)人，2009-2012。
2）、30972678/C080101 《Gq蛋白在T細(xì)胞死亡和功能中的作用及其作用機(jī)制研究》國家自然科學(xué)基金重點(diǎn)項(xiàng)目。課題負(fù)責(zé)人，2010-2012。

近期發(fā)表的論著目錄：

1. Dashan Wang, Yan Li, Yugao Zhang, Yuan Liu and Guixiu Shi. (2011) High-throughput screening (HTS) in identification new ligands and drugable targets of G protein-coupled receptors (GPCRs) . Combinatorial Chemistry & High Throughput Screening. 15: 232-241
2. Wang, Y., Li, Y.，He, Y.，Sun, Y.，Sun, W.，Xie, Q.，Yin, G.，Du, Y.，Wang, L.，Shi, G. (2011) Expression of G protein alphaq Subunit is Decreased in Lymphocytes from Rheumatoid Arthritis Patients and is Correlated with Disease Activity. Scand J Immunol Sep 16. doi: 10.1111/j.1365-3083.2011.02635.x. [Epub ahead of print]
3. Ravi S. Misra, Guixiu Shi(并列第一), Miguel E. Moreno-Garcia, Anil Thankappan, Michael Tighe, Betty Mousseau, Kim Kusser, Shirly Becker-Herman, Kelly L. Hudkins, Robert Dunn, Marilyn R. Kehry, Thi-Sau Migone, Ann Marshak-Rothstein, Melvin Simono, Troy D. Randall, Charles E. Alpers, Denny Liggitt, David J. Rawlings, and Frances E. Lund （2010）Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity. Journal of Experimental Medicine. 2010, July (epub ahead of print: doi: 10.1084/jem. 20092735) . (IF： 15.612 ).
4. Jun Ouyang, Duan-gai Wen, Caibin Fan, Jianquan Hou, Xueguang Zhang, Guixiu Shi ( 2010）Donor antigen loaded IKK2dn gene modified dendritic cells prolong allo-graft survival Scandinavian Journal ofIimmunology, 71（5）：336-344）
5. Ruixia Li, Gang Liu, Kai Wang, Yixin Liu, Qibing Xie, Yi Liu and Guixiu Shi. (2009) Splenectomy for thrombocytopenia associated with systemic lupus erythematosus in 11 Chinese patients. Rheumatology International 2009 Nov 3. [Epub ahead of print]
6. Guihua Zhu, Gang Liu, Yixin Liu, Qibing Xie, Guixiu Shi. (2009) Liver abnormalities in adult onset Still's disease: a retrospective study of 77 Chinese patients. J Clin Rheumatol. 2009 Sep;15(6):284-8
7. Guixiu Shi, Santiago Partida-Sánchez, Michael Tighe, Michael T. Borchers, Melvin I. Simon, and Frances E. Lund。 (2007) Identification of an alternative Gaq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. Journal of Experimental Medicine. 204(11): 2705-2718. (IF： 15.612 ).
8. Guixiu Shi, Hongyu Luo, Xiaochun Wan, Theodora W. Salcedo, Jun Zhang, and Jiangping Wu. (2002) Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 100:3279. (IF: 10.370; 被引用: 33次)
9. Guixiu Shi, Yulian Wu, Jun Zhang and Jiangping Wu. (2003) Death Decoy Receptor DcR3/TR6 Inhibits in vitro and in vivo T-Cell Chemotaxis. Journal of immunology 171:3407 (IF: 6.387; 被引用: 12次)
10. Guixiu Shi, Jianning Mao, Guang Yu, Jun Zhang and Jiangping Wu. (2005) Tumor vaccine based on cell surface expression of DcR3/TR6. Journal of immunology 174: 4727
11. Santiago Partida-Sanchez, Andreas Gasser, Ralf Fliegert, Cornelia C. Siebrands, Werner Dammermann, Guixiu Shi, Betty J. Mousseau, Adriana Sumoza-Toledo, Harivadan Bhagat, Timothy F. Walseth, Andreas H. Guse and Frances E. Lund. (2007) Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells Is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction. Journal of Immunology, 179: 7827-7839.
12. Partida-Sanchez S, Nava-Rivero L, Shi G, and Lund FE. (2007). CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. In: Crossroads between Innate and Adaptive Immunity. ADV EXP MED BIOL 590: 171-183
13. Guixiu Shi, Genevieve S. Young, Kim Kusser1, James B. Kirkland, Troy D.Randall1 and Frances E. Lund. (2006) Increased sensitivity of CD38 deficient islet cells to DNA damage: Role for NAD and PARP-1. Molecular Medicine 12: s23 (IF: 3.349)
14. Santiago Partida-Sanchez, Andreas Gasser, Ralf Fliegert, Adriana Sumoza-Toledo1, Harivadan Bhagat, Guixiu Shi, Timothy F Walseth4, Andreas H Guse3 andFrances E Lund. (2006) CD38 enzymatic products cADPR and ADPR control Ca2+ influx and leukocyte chemotaxis through TRPM2 cation channels. Molecular Medicine 12: s19. (IF: 3.349)
15. Yulian Wu, Bing Han, Hongyu Luo, Guixiu Shi, Jiangping Wu. (2004) Dipeptide Boronic Acid, a Novel Proteasome Inhibitor, Prevents Islet-Allograft Rejection. Transplantation. 78(3): 360.
16. Xiaochun Wan, Guixiu Shi, Mark Semenuk , Jun Zhang, Jiangping. (2003) DcR3/TR6 Modulates immune cell interactions.Journal of Cellular Biochemistry. 89(3): 603.
17. Xiaochun Wan, Jun Zhang, Hongyu Luo, Guixiu Shi, Elena Kapnik, Sunghee Kim, Palanisamy Kanakaraj and Jiangping Wu. (2002) A TNF family member reversely costimulatory signals in to human T cells. Journal of Immunology 169(12): 6813-21. 。


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