合肥工業(yè)大學(xué)生物與食品工程學(xué)院導(dǎo)師:汪惠麗

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合肥工業(yè)大學(xué)生物與食品工程學(xué)院導(dǎo)師:汪惠麗

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合肥工業(yè)大學(xué)生物與食品工程學(xué)院導(dǎo)師:汪惠麗 正文


  汪惠麗,女
  學(xué)歷學(xué)位:博士
  職稱:教授(研究員)
  電話:0551-2919397,15555115877
  E-mail:wanghl@hfut.edu.cn
  所屬學(xué)院:生物與食品工程學(xué)院

  個(gè)人簡(jiǎn)歷
  研究方向與主要項(xiàng)目:
  1)兒童鉛暴露影響腦發(fā)育和功能的細(xì)胞分子機(jī)制 2)突觸穩(wěn)態(tài)的調(diào)控機(jī)理 3)益智類功能食品的開發(fā)和應(yīng)用 4)食品安全和營(yíng)養(yǎng)的關(guān)鍵科學(xué)問(wèn)題

  代表論文:
  個(gè)人簡(jiǎn)介:
  汪惠麗,女,合肥工業(yè)大學(xué)生物與食品工程學(xué)院教授,“黃山青年學(xué)者”。從事神經(jīng)藥理學(xué)與毒理學(xué)、食品安全與營(yíng)養(yǎng)的教學(xué)和研究。美國(guó)神經(jīng)科學(xué)學(xué)會(huì)會(huì)員,中國(guó)神經(jīng)毒理學(xué)會(huì)理事,安徽省神經(jīng)科學(xué)學(xué)會(huì)理事,安徽省環(huán)境誘變劑學(xué)會(huì)理事。2006年畢業(yè)于中國(guó)科學(xué)技術(shù)大學(xué)生命科學(xué)學(xué)院,獲理學(xué)博士學(xué)位。博士畢業(yè)后在中國(guó)科學(xué)技術(shù)大學(xué)從事博士后研究,主持教育部中國(guó)博士后科學(xué)基金和中國(guó)科學(xué)院王寬誠(chéng)博士后工作獎(jiǎng)勵(lì)基金。并參加了“以安慶鎮(zhèn)痛消瘤散為基礎(chǔ)的新型透皮抗癌藥的開發(fā)研究”和“光催化納米C60引起細(xì)胞自噬及對(duì)神經(jīng)退行性疾病治療的研究”等工作。2006年12月至2007年3月參加中國(guó)第二十三次南極科學(xué)考察隊(duì),赴南極長(zhǎng)城站考察。2008年9月至2010年底,在加州大學(xué)伯克萊分校(University of California,Berkeley)從事博士后研究工作。2011年1月至12月在斯坦福大學(xué)醫(yī)學(xué)院任Research Associate,從事突觸穩(wěn)態(tài)調(diào)控機(jī)理研究。2011年合肥工業(yè)大學(xué)以“黃山青年學(xué)者”人才引進(jìn)。主持國(guó)家科技部973項(xiàng)目中的課題“鉛暴露影響腦發(fā)育的細(xì)胞分子機(jī)制”(NO.2012CB525003)。曾作為主要成員參加了國(guó)家科技部973項(xiàng)目中的課題“環(huán)境鉛致神經(jīng)系統(tǒng)的損傷與修復(fù)機(jī)制”(No.2002CB512907)、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目“環(huán)境鉛致神經(jīng)系統(tǒng)學(xué)習(xí)記憶功能損傷與修復(fù)機(jī)制”(No.30630057)、中國(guó)科學(xué)院創(chuàng)新項(xiàng)目“鉛污染及其作用機(jī)理”(No.KZCX3-SW-437)等項(xiàng)目。2006年獲教育部自然科學(xué)二等獎(jiǎng)(環(huán)境鉛對(duì)兒童學(xué)習(xí)記憶功能的損傷及修復(fù)機(jī)制研究,排名第4)。已發(fā)表論文30余篇,其中SCI論文20余篇,一些論文發(fā)表在生物科學(xué)領(lǐng)域重要雜志如“Journal of Neuroscience”(featured article);“Environmental Health & Perspectives”;“European Journal of Neuroscience”上。其中,2011年發(fā)表在“Journal of Neuroscience”上的“JDecrease in Calcium Concentration Triggers Neuronal Retinoic Acid Synthesis during Homeostatic Synaptic Plasticity”被Faculty of 1000評(píng)為“必讀”論文。多次參加國(guó)際、國(guó)內(nèi)學(xué)術(shù)會(huì)議,先后于2009年在美國(guó)冷泉港(Cold Spring Harbor)國(guó)際會(huì)議中心、2011年在Washington DC國(guó)際神經(jīng)科學(xué)年會(huì)(Society for Neuroscience)應(yīng)邀作大會(huì)報(bào)告,研究成果受到國(guó)際同行的高度關(guān)注。

  代表論著與論文:
  中國(guó)科學(xué)技術(shù)大學(xué)精品教材 《神經(jīng)生物學(xué)》(中國(guó)科學(xué)技術(shù)大學(xué)出版社,2008)編委
  1.Hui-Li Wang,Zhenjie Zhang,Maik Hintze,Lu Chen.Decrease in Calcium Concentration Triggers Neuronal Retinoic Acid Synthesis during Homeostatic Synaptic Plasticity.Journal of Neuroscience,2011,31 (49):17764-17771 ( featured article,SCI,IF:8.2)
  2.Peter Hastie,Max Ulbrich,Hui-Li Wang,Ehud Isaccoff,Lu Chen.Single-molecule imaging reveals concentration and subtype dependence of TARP—AMPA receptor interactions.(In revision,Proc Natl Acad Sci U S,IF:9.432)
  3.Hui-Li Wang,Xiang-Tao Chen,Bin Yang,F(xiàn)ang-Li Ma,Shu Wang,Ming-Liang Tang,Ming-Gao Hao,Di-Yun Ruan,Case-Control Study of Blood Lead Levels and Attention-Deficit Hyperactivity Disorder in Chinese Children,Environmental Health Perspectives,2008,116 (10):1401-1406 (SCI- 1區(qū),環(huán)境衛(wèi)生類Top1 雜志,IF:6.191)
  4.Hui-Li Wang,Xiang-Tao Chen,Le Luo,et al.Reparatory Effects of Nicotine on NMDA Receptor-mediated Synaptic Plasticity in the Hippocampal CA1 Region of Chronically Lead-exposed Rats.European Journal of Neuroscience,2006,23:1111-1119 (SCI- Ⅱ區(qū),IF:3.82)
  5.Hui-Li Wang,Xiang-Tao Chen,Shu-Ting Yin,Chuan-Yun Wu,Ming-Liang Tang,Di-Yun Ruan,Opposite Effects of α-Lipoic Acid on Antioxidation and Long Term Potentiation in Control and Chronically Lead-exposed Rats,Naunyn-Schmiedeberg’s Archives of Pharmacology,2008,378:303-310 (IF:2.631))
  6.Chuan-yun Wu,Bing Liu,Hui-li Wang,Di-yun Ruan.Levothyroxine rescues the lead-induced hypothyroidism and impairment of long-term potentiation in hippocampal CA1 region of the developmental rats.Toxicology and Applied Pharmacology,2011,(256):191-197 (IF:4.0)
  7.Hao Sun,Hui-Li Wang,Shu Wang.d-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro,Neuroscience Letters 417 (2007) 118–122
  8.Shu Wang,Pu Hu,Hui-Li Wang,Ming Wang,Ju-Tao Chen,Jiu-Lai Tang,Di-Yun Ruan Effects of Cd2+ on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area,Toxicology Letters,2008,176(3):215-222
  10.Tang M,Xin T,Zeng J,Wang H,Li C,Yin S,Yan D,Deng H,Liu J,Wang M,Chen J,Ruan DY.Unmodified CdSe Quantum Dots Induced Elevation of Cytoplasmic Calcium Levels and Impairment of Functional Properties of Sodium Channels in Rat Primary Cultured Hippocampal Neurons,Environ Health Perspect:2008,116(7):915-922.
  11.Mingliang Tang,Ming Wang,Tairan Xing,Jie Zeng,Huili Wang,Di-Yun Ruan.Mechanisms of Unmodified CdSe Quantum Dot-Induced Elevation of Cytoplasmic Calcium Levels in Primary Cultures of Rat Hippocampal Neurons.Biomaterials,2008,29 (33):4383-4391
  12.Shu Wang,Yan Gu,Hui-Li Wang,et al.Inhibitory Effect of Cd2+ on Glycine-induced Chloride Current in Rat Hippocampal Neurons,Brain Research Bulletin,2006,69:680–686
  13.Xiang-Tao Chen,Jun Li,Hui-Li Wang,et al.Immunomodulating Effects of Fractioned Polysaccharides Isolated from Yu-Ping-Feng-Powder in Cyclophosphamide-Treated Mice.American Journal of Chinese Medicine,2006,34 (4):631-641
  14.Chenchen Li ,Xinmei Li ,Weiheng Chen ,Shanshan Yu ,Jutao Chen ,Huili Wang and Diyun Ruan The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice hippocampus area CA1,BMC Developmental Biology,2007,7(1):57
  15.Shan-Shan Yu,Ming Wang,Xin-Mei Li,Wei-Heng Chen,Ju-Tao Chen,Hui-Li Wang and Di-Yun Ruan,Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure,BMC Developmental Biology,2007,7(1):51
  16.Li Su,Ming Wang,Shu-Ting Yin,Hui-Li Wang,Liang Chen,Li-Guang Sun,Di-Yun Ruan.,The interaction of selenium and mercury in the accumulations and oxidative stress of rat tissues.Ecotoxicology and Environmental Safety.2008,70:483-489
  17.Pu Hu ,Lei Sun ,Zhi-Qiang Zhu ,Shu Wang ,Shan-Shan Yu ,Ping Zhang,Ming Wang,Hui-Li Wang,Li-wen Niu,Mai-kun Teng,Di-Yun Ruan,Crystal structure and electrophysiological characterization of Natratoxin,a novel snake sPLA2 neurotoxin inhibiting A-type K+ currents,PROTEINS:Structure,F(xiàn)unction,and Bioinformatics,2008,72(2):673-683
  18.Chenchen Li,Tairan Xing,Mingliang Tang,Wu Yong,Dan Yan,Hongmin Deng,Huili Wang,Ming Wang,Jutao Chen,and Diyun Ruan*,Involvement of cyclinD1/CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb2+-induced neuronal death in cultured hippocampal neurons,Toxicology and Applied Pharmacology,2008,229:351-361
  19.Dan Yan,Lang Wang,F(xiàn)ang-li Ma,Hongmin Deng,Jin Liu,Chenchen Li,Huili Wang,Jutao Chen,Jiu-Lai Tang and Di-Yun Ruan,Developmental exposure to lead causes inherent changes on voltage-gated sodium channels in rat hippocampal CA1 neurons,Neuroscience,2008,153:436-445
  20.Shu Wang,Tai-Ran Xing,Ming-Liang Tang,Wu Yong,Chen-Chen Li,Liang Chen,Hui-Li Wang,Jiu-Lai Tang,Di-Yun Ruan*,Effects of Cd2+ on transient outward and delayed rectifier potassium currents in acutely isolated rat hippocampal CA1 neurons.Naunyn-Schmiedeberg Archives of Pharmacology,2008,377:245-253.
  21.Shu-Ting Yin;Ming-Liang Tang;Li Su;Liang Chen;Pu Hu;Hui-Li Wang;Ming Wang;Effects of Epigallocatechin-3-gallate on lead-induced oxidative damage,Toxicology.2008,249(1):45-54
  22.Pu Hu,Ming Wang,Wei-Heng Chen,Ji Liu,Liang Chen,Shu-Ting Yin,Wu Yong,Ju-Tao Chen,Hui-Li Wang,Jiu-Lai Tang,and Di-Yun Ruan.Protective effects of Quercetin against lead-induced impairment of synaptic plasticity in hippocampal Dentate Gyrus of rats in vivo,Naunyn-Schmiedeberg’s Archives of Pharmacology,2008,378(1):43-51.
  23.Dan Yan,Lang Wang,F(xiàn)ang-li Ma$ ,Hongmin Deng,Jin Liu,Chenchen Li,Huili Wang,Jutao Chen,Di-Yun Ruan,Developmental exposure to lead causes inherent changes on voltage-gated sodium channels in rat hippocampal CA1 neurons,Neuroscience,2008,153:436-445
  24.Ming-Liang Tang,Le Luo,Da-Miao Zhu,Hui-Li Wang,Yun-Yun Luo,Di-Yun Ruan*,Muscarinic Cholinergic Modulation of Synaptic Transmission and Plasticity in Rat Hippocampus following Chronic Lead Exposure.Naunyn-Schmiedeberg Archives of Pharmacology,Naunyn-Schmiedeberg Archives of Pharmacology,379(1):37-45,-2009
  25.Zhao QH,Zhang Y,Liu Y,Wang HL,Shen YY,Yang WJ,Wen LP.Anticancer effect of realgar nanoparticles on mouse melanoma skin cancer in vivo via transdermal drug delivery.Med Oncol,2009 (DOI 10.1007/s12032-009-9192-1)
  26.Wu Yong,Tai-Ran Xing,ShuWang,Liang Chen,Pu Hu,Chen-ChenLi,Hui-li Wang,Ming Wang,Ju-Tao Chen,Di-Yun Ruan.Protective Effects of Gastrodin on Lead-Induced Synaptic Plasticity Deficits in Rat Hippocampus.Planta Med,2009,75(10):1112-7
  International meetings:
  1.Hui-Li Wang,Zhenjie Zhang,Lu Chen.Calcium regulates neuronal retinoic acid synthesis
  during homeostatic synaptic plasticity.2011.11.SFN (Society for Neuroscience) annual meeting,Washington DC,USA.2.Wang,Hui-Li,Chen,Lu.Single-molecule imaging reveals concentration and subtype dependence of TARP—AMPA receptor interactions.SYNAPSES:FROM MOLECULES TO CIRCUITS & BEHAVIOR,2009,4.Cold Spring Harbor Laboratory,New York,USA
  3.Hui-Li Wang.Effect of nicotine on the NMDA-receptor dependent synaptic plasticity in the Hippocampal CA1 Region of Chronically Lead-exposed Rats.首屆華人地理學(xué)家大會(huì),2005,8 中國(guó)北京(北京大學(xué))
  4.WANG Hui-li,RUAN Di-yun.Effects of nicotine and α­­-lipoic acid on lead-induced long-term potentiation impairment.The 4th international congress of Asian society of toxicology (AXIATOX-Ⅳ) 2006,6.Zhuhai,China.5.Diyun Ruan,Huili Wang,Le Luo.Cholinergic modulation of synaptic transmission and plasticity in rat hippocampus following chronic lead exposure.The first international conference on frontiers in biomedical and environmental health sciences from molecular and systems biology to human diseases.2006,6.Wuhan,China.

  成果與榮譽(yù):
  科研項(xiàng)目和獲獎(jiǎng):
  2010年,安徽省第六屆自然科學(xué)優(yōu)秀學(xué)術(shù)論文一等獎(jiǎng)(排名第一)
  2007年,教育部自然科學(xué)獎(jiǎng) 二等獎(jiǎng)(No.2006-102)“環(huán)境鉛對(duì)兒童學(xué)習(xí)記憶功能的損傷及修復(fù)機(jī)制研究”,第4作者。
  2012~2016年,主持正在立項(xiàng)的973項(xiàng)目課題“鉛暴露影響腦發(fā)育的細(xì)胞分子機(jī)制”(No.2012CB525003)。
  2007年,主持教育部中國(guó)博士后科學(xué)基金項(xiàng)目(No.20060400719)
  2006年,主持中國(guó)科學(xué)院王寬誠(chéng)博士后工作獎(jiǎng)勵(lì)基金項(xiàng)目。
  2006-2008年,作為主要成員參加了國(guó)家科技部973項(xiàng)目 “環(huán)境鉛致神經(jīng)系統(tǒng)的損傷與修復(fù)機(jī)制(No.2002CB512907)”、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目“環(huán)境鉛致神經(jīng)系統(tǒng)學(xué)習(xí)記憶功能損傷與修復(fù)機(jī)制(No.30630057)”、中國(guó)科學(xué)院創(chuàng)新項(xiàng)目“鉛污染及其作用機(jī)理(No:KZCX3-SW-437)”。
  2008.9~2010.12,參加美國(guó)國(guó)立衛(wèi)生院NIMH“MECHANISM OF STARGAZIN-REGULATED AMPAR TRAFFICKING(stargazin 調(diào)控AMPA受體轉(zhuǎn)運(yùn)機(jī)制)”(項(xiàng)目號(hào):1 R01 MH069792),排名第三。
  2008.9~2010.9 參加美國(guó)W.M.Keck Foundation Distinguished Young Scholars in Medical Research研究。
  2008.10~2010.10 參加The David and Lucile Packard Foundation基金會(huì)資助項(xiàng)目。
  2011.2~2011.8,參加美國(guó)國(guó)立衛(wèi)生院NIMH項(xiàng)目“Synaptic function of retinoic acid study(全反式維甲酸的突觸功能研究”)(項(xiàng)目號(hào):1R01 MH091193)。排名第三。
  2009.11~2011.8,參加美國(guó)國(guó)立衛(wèi)生院NIMH項(xiàng)目(項(xiàng)目號(hào):1P50MH086403)Conte center 研究,排名第四。
  2006.12~2007.3,參加中國(guó)第二十三次南極科學(xué)考察隊(duì),赴南極考察。
  2008年,參加安徽省科技攻關(guān)項(xiàng)目“以安慶鎮(zhèn)痛消瘤散為基礎(chǔ)的新型透皮抗癌藥的開發(fā)研究”

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