蘭州大學(xué)研究生導(dǎo)師：茍小平 正文

　　學(xué)習(xí)經(jīng)歷

　　1998.09-2001.07：四川大學(xué)生命科學(xué)學(xué)院植物學(xué)專業(yè)，理學(xué)博士

　　1995.09-1998.07：四川大學(xué)生命科學(xué)學(xué)院植物學(xué)專業(yè)，理學(xué)碩士

　　1991.09-1995.07：四川大學(xué)生物系植物學(xué)專業(yè)，理學(xué)學(xué)士

　　1998.09-2001.07:  Ph.D., Botany, College of Life Sciences, Sichuan University

　　1995.09-1998.07:  M.S., Botany, College of Life Sciences, Sichuan University

　　1991.09-1995.07:  B.S., Botany, Department of Biology, Sichuan University

　　工作經(jīng)歷

　　2009.10－目前：      蘭州大學(xué)萃英特聘教授，博士生導(dǎo)師，蘭州大學(xué)生命科學(xué)學(xué)院

　　2001.10－2009.09：博士后，The University of Oklahoma，USA

　　2009.10-Present:      Professor of plant biology, School of Life Sciences, Lanzhou University, China

　　2001.10-2009.9:       Postdoctoral research associate, Department of Microbiology and Plant Biology, University of Oklahoma, USA

　　教學(xué)及指導(dǎo)研究生情況

　　1、研究生招生（Masters and Ph.D. Programs）：

　　碩士研究生招生  專業(yè)：植物學(xué)（071001）；方向：植物分子生物學(xué)、植物分子發(fā)育生物學(xué)、植物細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)

　　博士研究生招生  專業(yè)：植物學(xué)（071001）；方向：植物分子遺傳學(xué)、植物分子發(fā)育生物學(xué)、植物生殖生物學(xué)

　　目前指導(dǎo)博士研究生8人，碩士研究生6人。

　　歡迎報(bào)考博士、碩士研究生，合作開展博士后研究工作。

　　Major for master students: Plant Biology (Plant Molecular Biology, Plant Developmental Biology, Plant Cell Signaling)

　　Major for Ph.D. students: Plant Biology (Plant Molecular Genetics, Plant Developmental Biology, Plant Reproductive Biology)

　　2、教學(xué)（Teaching）：

　　植物生殖與發(fā)育生物學(xué)（秋季，本科生）／Plant Reproductive & Developmental Biology (Fall, Undergraduate)

　　植物生殖生物學(xué)（秋季，研究生）／Plant Reproductive Biology (Fall, Graduate)

　　分子克隆與基因工程（秋季，研究生）／Molecular Cloning & Genetic Engineering (Fall, Graduate)

　　本科生科研訓(xùn)練（本科生）／Independent Study Courses in Plant Biology (Spring/Fall, Undergraduate)

　　發(fā)表論文及專著

　　Du J, Gao Y, Zhan Y, Zhang S, Wu Y, Xiao Y, Zou Bo, He K, Gou X, Li G, Lin H, Li J. (2016). Nucleocytoplasmic trafficking is essential for BAK1 and BKK1-mediated cell-death control. Plant Journal, doi: 10.1111/tpj.13125.

　　Zhang J, Yuan T, Duan X, Wei X, Li J, Russell SD, Gou X. (2016). Cis-regulatory elements determine germline specificity and expression level of an isopentenyltransferase gene in sperm cells of Arabidopsis. Plant Physiology, doi:10.1104/pp.15.01510.

　　Yue J, Qin Q, Meng S, Jin H, Gou X, Li J, Hou S. (2016). TOPP4 regulates the stability of phytochrome interacting factor 5 during photomorphogenesis in Arabidopsis. Plant Physiology, doi:10.1104/pp.15.01729.

　　Wu Y, Xun Q, Guo Y, Zhang J, Cheng K, Shi T, He K, Hou S, Gou X, Li J. (2016) Genome-wide expression pattern analyses of the Arabidopsis leucine-rich repeat receptor-like kinases. Molelular Plant, 10.1016/j.molp.2015.12.011.

　　Shi T, Dimitrov I, Zhang Y, Tax FE, Yi J, Gou X, Li J. (2015). Accelerated rates of protein evolution in barley grain and pistil biased genes might be legacy of domestication. Plant Molecular Biology, 89: 253-261.

　　Anderson S, Johnson C, Jones D, Conrad L, Gou X, Russell SD, Sundaresan V. (2013). Transcriptomes of isolated rice gametes characterized by deep sequencing: Evidence for distinct sex-dependent chromatin and epigenetic states before fertilization. Plant Journal, 76: 729-741.

　　Russell SD, Gou X, Wong CE, Wang XK, Yuan T, Wei XP, Bhalla PL, Singh MB. (2012). Genomic profiling of rice sperm cell transcripts reveals conserved and distinct elements in the flowering plant male germ lineage. New Phytologist, 195: 560-573.

　　Du J, Yin H, Zhang S, Wei Z, Zhao B, Zhang J, Gou X, Lin H, Li J. (2012). Somatice embryogenesis receptor kinases control root development mainly via brassinosteroid-independent actions in Arabidopsis thaliana. Journal of Integrative Plant Biology, 54: 388-399.

　　Gou X, Li J. (2012). Activation tagging. Methods in Molecular Biology, 876. DOI: 10.1007/978-1-61779-809-2_9.

　　Gou X, Yin H, He K, Du J, Yi J, Xu S, Lin H, Clouse SD, Li J. (2012). Genetic evidence for an indispensable role of somatic embryogenesis receptor kinases in brassinosteroid signaling. PLoS Genetics, 8: e1002452.

　　Li J, Du J, He K, Gou X. (2011). Control of cell death by Receptor Kinases in Arabidopsis thaliana. In "Receptor-like Kinases in Plants: From Development to Defense (eds Birgit Kemmerling and Frans Tax)". Signaling and Communication in Plants (ed. Frantisek Baluska, Springer Publisher), Volume 13, pp79-91.

　　An J, Guo Z, Gou X, Li, J. (2011) TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana. Plant Signaling & Behavior, 6: 1117-1118.

　　Ge L, Gou X, Yuan T, Strout GW, Nakashima J, Blancaflor EB, Tian HQ, Russell SD. (2010). Migration of sperm cells during pollen tube elongation in Arabidopsis thaliana: behavior during transport, maturation and upon dissociation of male germ unit associations. Planta, 233:325-332.

　　Guo Z, Fujioka S, Blancaflor EB, Miao S, Gou X, Li J. (2010). TCP1 controls brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana. Plant Cell 22, 1161-1173.

　　Russell SD, Gou X, Wei X, Yuan T. (2010). Male gamete biology in flowering plants. Biochemical Society Transactions 38, 598-603.

　　Yang H, Gou X, He K, Xi D, Du J, Lin H, Li J. (2010). BAK1 and BKK1 in Arabidopsis thaliana confer reduced susceptibility to turnip crinkle virus. European Journal of Plant Pathology 127, 149-156.

　　Gou X, He K, Yang H, Yuan T, Clouse SD, Li J. (2010). Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics 11, 19.

　　Gou X, Yuan T, Wei X, Russell SD. (2009). Gene expression in the dimorphic sperm cells of Plumbago zeylanica: Transcript profiling, diversity, and relationship to cell type. Plant Journal 60, 33-47.

　　He K, Gou X, Powell RA, Yang H, Yuan T, Guo Z, Li J. (2008). Receptor-like protein kinases, BAK1 and BKK1, regulate a light-dependent cell-death control pathway. Plant Signaling & Behavior 3: 813-815.

　　Li J, Gou X. (2007). Brassinosteroids. In Handbook of plant science (Roberts, K., ed). John Wiley & Sons, Ltd, pp. 395-404.

　　He K, Gou X, Yuan T, Lin H, Asami T, Yoshida S, Russell SD, Li J. (2007). BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. Current Biology 17, 1109-1115.

　　Yuan T, Fujioka S, Takatsuto S, Matsumoto S, Gou X, He K, Russell SD, Li J. (2007). BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. Plant Journal 51, 220-233.

　　Wei X, Gou X, Yuan T, Russell SD. (2006). A highly efficient in vitro plant regeneration system and Agrobacterium-mediated transformation in Plumbago zeylanica. Plant Cell Rep 25, 513-521.

　　研究方向

　?。?）受體激酶介導(dǎo)的細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)。受體激酶（RLKs）分布在細(xì)胞表面，從胞外環(huán)境獲取信號(hào)并傳遞到細(xì)胞內(nèi)啟動(dòng)下游的基因表達(dá)和調(diào)控，從而讓植物體對(duì)各種信號(hào)作出正確的反應(yīng)。在擬南芥中有600個(gè)以上的受體激酶，到目前為止只對(duì)其中很少一部分基因的功能有所了解。我們克隆了其中絕大部分受體激酶的全長(zhǎng)cDNA，并轉(zhuǎn)化野生型擬南芥進(jìn)行了超表達(dá)，目前正致力于解析這些受體激酶的生物學(xué)功能。

　　Functional Analysis of Receptor Kinases

　　There are more than 600 receptor-like kinases (RLKs) in Arabidopsis that locate on the surface of cells to perceive and transduce chemical signals into cells, regulating downstream gene expression and responding to a variety of biotic or abiotic stimuli. So far, biological functions have been defined for only a handful of RLKs that play crucial roles in many physiological processes in plant. My research is focusing on revealing the functions of these RLKs. Preliminary studies showed that gene members of a couple of RLK subfamilies regulate anther and ovary development, and zygotic embryogenesis, which is under intensive investigation.

　　（2）植物生殖生物學(xué)。被子植物雙受精是一個(gè)復(fù)雜的過程，一個(gè)精細(xì)胞與卵細(xì)胞融合形成合子，發(fā)育成胚胎，是下一代植物的雛形；另一個(gè)精細(xì)胞與中央細(xì)胞融合形成胚乳，為胚胎發(fā)育提供營(yíng)養(yǎng)。雙受精的成敗關(guān)系到植物種群的延續(xù)，同時(shí)也關(guān)系到絕大部分農(nóng)作物的產(chǎn)量與質(zhì)量。實(shí)驗(yàn)室目前的工作主要是利用模式植物擬南芥研究雌雄生殖器官以及性細(xì)胞發(fā)育調(diào)控的分子機(jī)理，以及早期胚胎發(fā)育調(diào)控的信號(hào)途徑。

　　Plant Reproductive Biology

　　Double fertilization is a very complex biological process of angiosperms. After transferred into embryo sac by pollen tube, one sperm cell fuses with the egg cell, forming the zygote that will develop into the embryo, and the other sperm cell fuses with the center cell to generate the endosperm that provides nutrients for embryo development. Successful double fertilization is critical for the survival and development of every species, and is also crucial for the quantity and quality of the production of many crops. Plants have complex regulatory systems to regulate the development of sexual organs to achieve successful double fertilization and embryogenesis. My current research is focusing on those genes involved in anther, ovule and embryo development.

　　項(xiàng)目成果

　　實(shí)驗(yàn)室得到國(guó)家自然科學(xué)基金委員會(huì)、教育部、科技部和蘭州大學(xué)的經(jīng)費(fèi)支持。

　　1、主持項(xiàng)目：

　　國(guó)家自然科學(xué)基金面上項(xiàng)目《擬南芥富含亮氨酸重復(fù)類受體激酶調(diào)控合子胚胎發(fā)育的分子機(jī)理》（No.31070283）

　　國(guó)家自然科學(xué)基金面上項(xiàng)目《擬南芥珠被發(fā)育的信號(hào)網(wǎng)絡(luò)與調(diào)控機(jī)理》（No.31270229）

　　國(guó)家自然科學(xué)基金面上項(xiàng)目《PzIPT1在擬南芥精細(xì)胞中表達(dá)的分子機(jī)理研究》（No.31471402）

　　教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃項(xiàng)目《受體激酶調(diào)控花藥發(fā)育的分子機(jī)理》（No. NCET-12-0249）

　　教育部科學(xué)技術(shù)項(xiàng)目《受體激酶SERKs調(diào)控?cái)M南芥胚胎發(fā)育的信號(hào)通路》（No.113058A）

　　2、參加項(xiàng)目：

　　國(guó)家自然科學(xué)基金重大研究計(jì)劃重點(diǎn)項(xiàng)目《一類植物特有的轉(zhuǎn)錄因子TCP在油菜素內(nèi)酯生物合成及信號(hào)轉(zhuǎn)導(dǎo)中的調(diào)控機(jī)理》（No.90917019）

　　教育部“長(zhǎng)江學(xué)者和創(chuàng)新團(tuán)隊(duì)發(fā)展計(jì)劃”創(chuàng)新團(tuán)隊(duì)項(xiàng)目《植物多重抗逆的分子機(jī)理》（Nos.IRT0924, IRT_13R25）

　　科技部重大科學(xué)研究計(jì)劃課題《植物蛋白的修飾的重要過程與調(diào)控機(jī)理》（No.2011CB9154001）

　　榮譽(yù)、獲獎(jiǎng)

　　教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃（2012）

 

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